Zika

Mosquito virus causing birth defects. Flavivirus linked to microcephaly and Guillain-Barré syndrome.

Key facts

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Prior dengue infection creates antibodies that enhance Zika cell entry through ADE, increasing viral loads during pregnancy. This enhanced replication is particularly devastating when it occurs during the critical 10-20 week neurotropism window, leading to more severe microcephaly in dengue-endemic regions.

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