Leishmaniasis

Parasite causing 'Baghdad boil' - chronic skin ulcers in Middle Eastern regions. Sandfly-transmitted protozoan causing cutaneous ulcers or fatal visceral disease (kala-azar).

Key facts

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Leishmaniasis recidivans is characterized by reactivation of latent amastigotes after prolonged clinical quiescence (20-40 years), typically triggered by immunocompromise, physiological stress, or immunosenescence. These dormant parasites persist in tissue macrophages, evading immune surveillance until host immune competence becomes compromised, leading to renewed parasite multiplication and clinical manifestation.

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